Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints
Identifieur interne : 002201 ( Main/Exploration ); précédent : 002200; suivant : 002202Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints
Auteurs : D. Santilli [Italie] ; A. Lo Monaco [Italie] ; P L Cavazzini [Italie] ; F. Trotta [Italie]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2002-06.
English descriptors
- KwdEn :
- Teeft :
- Alkylating agents, Arthritis, Arthritis rheum, Arthropathy, Breast cancer, Case report, Degli studi, Destructive arthropathy, Diagnostic investigation, Distal interphalangeal, Erosive, Erosive changes, Erosive polyarthritis, Ferrara, Gouty arthritis, Immunohistochemical analysis, Interphalangeal, Joint space, Malignancy, Methotrexate, Multicentric, Multicentric reticulohistiocytosis, Multinucleated, Multinucleated giant cells, Nger, Nger joints, Nodal, Node, Osteoarthritis, Osteoarticular disorders, Other hand, Prominent involvement, Psoriatic, Psoriatic arthritis, Pulse methotrexate, Radiological, Radiological evidence, Reticulohistiocytosis, Rheum, Rheumatoid, Rheumatoid arthritis, Rheumatol, Semin arthritis rheum, Skin nodules, Subchondral, Synovial, Synovial membrane, Tophaceous, Tophaceous gout, Trotta, Typical skin lesions.
Abstract
Background: Multicentric reticulohistiocytosis (MRH) is a rare systemic disease, presenting with typical skin abnormalities and erosive polyarthritis, which is often associated with malignancy. Case report: A case of MRH arthropathy, in which the typical nodular skin manifestation of the disease was absent, is described in a patient with a past history of breast cancer and no evidence of recurrent or new malignancy. Results: Careful clinical and roentgenological evaluation disclosed important clues to differentiate this condition from other more common distal interphalangeal arthritides—namely, osteoarthritis and its “erosive” variant, rheumatoid arthritis, psoriatic arthritis, tophaceous gout, dialysis related hand arthropathy, and from the rarer fibroblastic rheumatism, all of which can be mimicked by MRH. Histopathology showed the characteristic histiocytic and multinucleated giant cell infiltrate with ground glass cytoplasm, and immunohistochemical analysis showed markers evocative of a monocyte/macrophage origin of MRH.
Url:
DOI: 10.1136/ard.61.6.485
Affiliations:
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Santilli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Unità Operativa di Reumatologia, Azienda Ospedaliera-Universitaria “Arcispedale S Anna” and Università degli Studi di Ferrara, Ferrara, 44100</wicri:regionArea><wicri:noRegion>44100</wicri:noRegion></affiliation></author><author><name sortKey="Lo Monaco, A" sort="Lo Monaco, A" uniqKey="Lo Monaco A" first="A" last="Lo Monaco">A. 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Case report: A case of MRH arthropathy, in which the typical nodular skin manifestation of the disease was absent, is described in a patient with a past history of breast cancer and no evidence of recurrent or new malignancy. Results: Careful clinical and roentgenological evaluation disclosed important clues to differentiate this condition from other more common distal interphalangeal arthritides—namely, osteoarthritis and its “erosive” variant, rheumatoid arthritis, psoriatic arthritis, tophaceous gout, dialysis related hand arthropathy, and from the rarer fibroblastic rheumatism, all of which can be mimicked by MRH. Histopathology showed the characteristic histiocytic and multinucleated giant cell infiltrate with ground glass cytoplasm, and immunohistochemical analysis showed markers evocative of a monocyte/macrophage origin of MRH.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Santilli, D" sort="Santilli, D" uniqKey="Santilli D" first="D" last="Santilli">D. Santilli</name></noRegion><name sortKey="Cavazzini, P L" sort="Cavazzini, P L" uniqKey="Cavazzini P" first="P L" last="Cavazzini">P L Cavazzini</name><name sortKey="Lo Monaco, A" sort="Lo Monaco, A" uniqKey="Lo Monaco A" first="A" last="Lo Monaco">A. Lo Monaco</name><name sortKey="Trotta, F" sort="Trotta, F" uniqKey="Trotta F" first="F" last="Trotta">F. Trotta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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